Description
Product Characteristics:
UBE2G2 (Ubiquitin-conjugating enzyme E2 G2), also known as UBC7, is a 165 amino acid protein involved in ubiquitin-mediated protein degradation. Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBE2G2 is an E2 ubiquitin-conjugating enzyme that acts to catalyze the covalent attachment of ubiquitins to various proteins. Expressed throughout the body, UBE2G2 shares 100 % sequence identity with its mouse counterpart and is thought to be involved in endoplasmic reticulum-associated degradation (ERAD). Two isoforms of UBE2G2 exist due to alternative splicing events.
Subcellular location: Cytoplasm
Synonyms: Human ubiquitin conjugating enzyme G29, UB2G2_HUMAN, UBC 7, UBC7, UBC7 homolog yeast, UBE2G2, Ubiquitin carrier protein G2, Ubiquitin conjugating enzyme 7, Ubiquitin conjugating enzyme E2 G2, Ubiquitin conjugating enzyme E2G 2 homologous to yeast UBC7, Ubiquitin conjugating enzyme E2G 2 UBC7 homolog yeast, Ubiquitin conjugating enzyme E2G 2, Ubiquitin conjugating enzyme G2, Ubiquitin protein ligase G2, Ubiquitin-conjugating enzyme E2 G2, Ubiquitin-protein ligase G2.
Target Information: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]